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BrainVTA

Construction and Packaging Service of virus Vector

Construction and Packaging Services of AAV

Large scale AAV production

Adeno-Associated Virus (AAV)
Adeno-associated virus (AAV) was discovered in 1965, as a contaminant of adenovirus (Ad) preparations, hence the name. It is replication-defective, non-enveloped small viruses (20nm) with a genome of single stranded DNA, from the parvovirus family. As 80-90% of humans are sero-positive with AAV2, most people treated with AAVs are non-pathogenic. Recombinant AAVs can infect both dividing and non-dividing cells and persist in an extrachromosomal state without integrating into the genome of the host cell.

How do I obtain virus packaging services?
BrainVTA provide professional,convenient and R & D products experienced service of AAV, ranging from small-scale to the large-scale, which help scientist accelerate the research process in circuit tracing, mechanisms of disease and treatment of disease.
So far, we have nearly 1000 pre-made AAV products with different serotypes and promoters. Meanwhile, we have offered 2000 customized AAV services for our clients with the following serotypes: AAV-1, AAV-2, AAV-5, AAV-6, AAV-8, AAV-DJ, AAV-PHP.eB, AAV-retro, AAV-anc80 and AAV-9. Artificially designed serotypes and vectors also can be produced on a case-by-case basis.
Please click Pre-Made AAVs for the in stock AAVs.
By clicking here for Custom-Made AAVs service.

Virus serotypes
BrainVTA currently offers the following serotypes: 1, 2, 5, 6, 8, 9, rh10, DJ, DJ8, PHP.B, PHP.eB, PHP.S, retro, pan, anc80. Novel peptide modified serotypes can also be produced on a case-by-case basis. Tissue specificity is determined by the serotype. If you Don't know which AAV serotype to use, see the following table to explore available AAV serotype to meet the efficient delivery of gene into the cells or tissues of interest.
 Serotype Tropism
AAV1 Muscle, heart, CNS, RPE, lung, skeletal muscle 
AAV2 In vitro, CNS, RPE, muscle, liver,CNS
AAV5 Lung, RPE, CNS, pancreas, adipose, liver
AAV6 Muscle, lung, heart
AAV8 Liver, muscle, RPE, CNS, adipose, pancreas
AAV-pan  Pancreas
AAV9 Lung, liver, muscle, heart, CNS, adipose, BBB
AAV.rh10 CNS, BBB, pleura
AAV-Rec2 Adipose
AAV.DJ In vitro, liver, heart, kidney
AAV2/RETRO Retro
AAV.PHP.S DRG, heart, colon
 AAV.PHP.B BBB
 AAV.PHP.eB BBB
 
Tissue-specific promoters
BrainVTA offers various tissue-specific promoters. Listed below are the most commonly chosen promoters. Don' see the promoter of interest, Please inquire.

NO. Name Characteristics Sizebp
Strong promoters
1 CMV Ubiquitous 584
2 CAG Ubiquitous 1678
3 CBA( Cbh ) Ubiquitous 793
4 n Ef1α Short  Ef1α,Ubiquitous 493
5 Ef1α Ubiquitous 1179
6 hUbC Ubiquitous 1130
Inducible promoters
1 TRE3G Tetracycline(Tet)-inducible 350
Activity–dependent promoters
1 C-fos Immediate-early gene promoter 662
2 E-SARE Enhanced synaptic activity–responsive  element 954
Neuron-specific promoters
1 Mecp2 Truncated Mcep2 neuron specific 230
2 hSyn Mature neuron specific 485
3 CaMKIIa Specific expression inexci-tatory neurons in the neocortex and hippocampus 1293
4 PV GABAergic neuron subtypes 2396
5 SST GABAergic neuron subtypes 2597
6 VGAT GABAergic neuron 1800
7 mDlX GABAergic neuron 530
8 TH Dopaminergic neuron specific 299
9 TPH2 Tryptophan hydroxylase promoter 2042
10 ChAT Cholinergic neuron specific 1500
11 GFAP Astrocyte specific 2207
12 GFAP104 Short  GFAP 845
13 Cx30GJB6) Astrocyte specific 1505
14 CX3CR1 Microglia specific 1263
15 Mash1/Ascl1 Neural stem cell specific 1469
16 Nestin Neural stem cell specific 1394
17 L7/Pcp2 Purkinje cell 990
18 MBP Myelin basic protein promoter, efficient transduction of oligodendrocytes 1300
19 TRPV1 Transient receptor potential cation channel, subfamily V, member 1 2073
20 TRPV2 Transient receptor potential cation channel, subfamily V, member 2 1700
21 D1 D1 dopamine receptor 827
22 D2 D2 dopamine receptor 1211
23 OT Oxytocin promoter 2612
24 CRH Corticotropin-Releasing Hormone (CRH) promoter 456
25 PTH Human parathyroid hormone promoter 925
Eye-specific promoters
1 hGRK1                 Human rhodopsin kinase promoter 292
2 CAR         Cone arrestin gene promoter 523
3 Grm6                Bipolar cell specific expression 200
4 mRHOP        Rhodopsin gene promoter 524
5 ROH          Rhodopsin gene promoter 2200
6 Nrl                  Neural retina leucine zipper gene promoter 3200
7 RK         Rhodopsin kinase promoter 295
Liver-specific promoters
1 ALB Albumin enhancer promoter 1001
2 TBG Serine (or cysteine) peptidase inhibitor, clade A 410

Ready to order?
Know what you need? Just click the Pre-Made AAVs or theCustom-Made AAVs Button and submit your needs to us.

50% discount for Pre-Made AAVs