Gene expression

Gene expression is the process of transforming the genetic information into a protein, which is widely uesd in gene function research. BrainVTA offers various solutions for gene expression though viral vectors.

Lentivirus
● High titer, >10⁸ TU/mL
● High transduction efficiency.
● Self-inactivated LV.
●Suitable for in vivo and in vitro experiments.
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AAVs
● High titer, ≥ 2×10¹²vg/ml
● 1000+ pre-made AAVs with different serotypes and promoters.
● 2000+ customized AAV services have beed offered.
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HSV
● High titer, >10⁸ IFU/mL
●Large DNA capacity（>5Kb）
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CRISPR-Cas9
● saCas9/spCas9-Knock In
● dCas9-activator
● AAV/LV
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Advantages
● Competitive pricing
● Fast turnaround
● Stringent quality control processes
● Consulting service with experienced scientists
● A lot of ready-to-use vectors with a wide variety of promoters, selection markers, and reporters.

Whole Delivery Formats
● Report
● Lentivirus or AAV virus.
Success Story

1. Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression. https://www.sciencedirect.com/science/article/pii/S2211124718309653
2. Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory. https://www.nature.com/articles/s41467-019-13236-9
3. Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis. http://doi.org/10.1084/jem.20180992
4. Locus coeruleus-CA1 projections are involved in chronic depressive stress-induced hippocampal vulnerability to transient global ischaemia.https://www.nature.com/articles/s41467-019-10795-9

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